We benchmark the performance of the Advantage2™ quantum-processing unit (QPU), a 4,400+ annealing quantum computer interconnected in the Zephyr™ topology, against a previous-generation QPU on the optimization task of solving 3D-lattice spin glasses of tunable precision. We present performance results that highlight the benefits of our latest fabrication upgrade, which yields significant improvements in solution quality over a range of test scenarios. In some cases, the Advantage2 system produces better quality solutions using anneal times that are several orders of magnitude faster than those used on the previous-generation Advantage™ system.